A DISTINCT CLASS OF ANTIBODIES MAY BE AN INDICATOR OF GRAY MATTER AUTOIMMUNITY IN EARLY AND ESTABLISHED RELAPSING REMITTING MULTIPLE SCLEROSIS PATIENTS

* These authors contributed equally to the work in this manuscript.We have previously identified a distinct class of antibodies expressed by B cells in the cerebrospinal fluid (CSF) of early and established relapsing remitting multiple sclerosis (RRMS) patients that is not observed in healthy donors.These antibodies contain a unique pattern of muta

Mary Lynn Davis-Ajami,1 Jun Wu,2 Katherine Downton,3 Emilie Ludeman,3 Virginia Noxon4 1Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, MD, USA; 2South Carolina College of Pharmacy, University of South Carolina, Greenville, SC, USA; 3Health Sciences and Human Services Library, University of Maryland, Bal

Lactic acid (LA) is a sensitive ointm indicator of exercise intensity and duration.A single bout of prolonged and intensive exercise can cause transient immunosuppression through the interaction of cellular, humoral, and hormone factors.Exercise-induced influences on neutrophil extracellular traps (NETs) release have been reported, but the underlyi

The causes of socioeconomic inequality have been debated since the time of Plato.Many reasons for the development of stratification have been proposed, from the need for hierarchical control over large-scale irrigation systems to the accumulation of small differences in Brooch wealth over time via inheritance processes.However, none of these explai

Background: Although preclinical models reveal the neurobiological pathways altered through opioid abuse, comprehensive assessments of gene expression in human brain samples are needed.Moreover, less is known about gene expression in response to fatal overdose.The primary goal of the present study was to compare gene expression in the dorsolateral